New York City FC will start the Concacaf Champions League Round of 16 on the road as the MLS Cup champions visit Santos de Guapiles in Costa Rica on Tuesday, Feb. 15 at 8 p.m. ET.

City will host the Central American side on Wednesday, Feb. 23 at 6 p.m. ET.

Venues will be announced by Concacaf in January.

The pairings for the Round of 16 and each club’s road to the final were determined at the official draw on Wednesday, December 15.

The 2022 edition will continue to be played in a direct elimination knockout format, with home and away play in all rounds of the competition. The calendar for the CCL Round of 16 is as follows:

(Home club listed first and kickoff times listed in eastern time (local time)

First leg

Tuesday, Feb. 15

6:00 PM (7:00 PM) Cavaly AS (HAI) vs New England Revolution (USA)
8:00 PM (7:00 PM) Santos de Guapiles (CRC) vs New York City FC (USA)
10:00 PM (9:00 PM) Santos Laguna (MEX) vs CF Montreal (CAN)

Wednesday, Feb. 16

6:00 PM (5:00 PM) CD Guastatoya (GUA) vs Club Leon (MEX)
8:00 PM (8:00 PM) Forge FC (CAN) vs Cruz Azul (MEX)
10:00 PM (9:00 PM) Deportivo Saprissa (CRC) vs Pumas UNAM (MEX)

Thursday, Feb. 17

8:00 PM (7:00 PM) Comunicaciones FC (GUA) vs Colorado Rapids (USA)
10:00 PM (9:00 PM) FC Motagua (HON) vs Seattle Sounders FC (USA)

Second leg

Tuesday, Feb. 22

6:00 PM (6:00 PM) New England Revolution (USA) vs Cavaly AS (HAI)
8:30 PM (8:30 PM) CF Montreal (CAN) vs Santos Laguna (MEX)
10:30 PM (9:30 PM) Club Leon (MEX) vs CD Guastatoya (GUA)

Wednesday, Feb. 23

6:00 PM (6:00 PM) New York City FC (USA) vs Santos de Guapiles (CRC)
8:30 PM (6:30 PM) Colorado Rapids (USA) vs Comunicaciones FC (GUA)
10:30 PM (9:30 PM) Pumas UNAM (MEX) vs Deportivo Saprissa (CRC)

Thursday, Feb. 24

8:30 PM (7:30 PM) Cruz Azul (MEX) vs Forge FC (CAN)
10:30 PM (7:30 PM) Seattle Sounders FC (USA) vs FC Motagua (HON)