Christian Pulisic and his USMNT teammates need to pick themselves up against Honduras. (Christopher Hanewinckel-USA TODAY Sports)

After earning only two points in its first two matches of World Cup qualifying, there is little doubt the pressure is on the U.S. men’s national in its third and final WCQ of September.

The Americans face a must win-situation as they meet Honduras in San Pedro Sula Wednesday night. It will be the USMNT’s third World Cup qualifier in seven days, the first set of games in a 14-match, seven-month gauntlet against the region’s best teams for a berth in the 2022 World Cup.

Kickoff from Estadio Olimpico Metropolitano is set for 10:30 p.m. ET on Paramount+, Telemundo and Universo. Fans can follow the USMNT during World Cup qualifying on Twitter (@USMNT), Instagram (@USMNT), Facebook and the official U.S. Soccer App.

The USA has had a pair of disappointing results – a 1-1 draw in El Salvador Sept. 2 and a 1-1 tie with Canada at home Sunday.

The USMNT several roster changes during the September international window. Goalkeeper Zack Steffen and midfielder Weston McKennie are no longer on the roster and have been replaced by goalkeeper Sean Johnson and midfielder Jackson Yueill, who both helped the USA win the 2021 Gold Cup this summer.

Sergino Dest (right ankle sprain) and Gio Reyna (right hamstring) have been ruled out of Wednesday’s match vs. Honduras due to injury. Forward Tim Weah was forced to withdraw from the roster prior to the camp with an injury suffered in training with his club.

The U.S. roster

GOALKEEPERS (3): Ethan Horvath (Nottingham Forest/ENG; 7/0), Sean Johnson (New York City FC; 9/0), Matt Turner (New England Revolution; 9/0)

DEFENDERS (9): George Bello (Atlanta United; 3/0), John Brooks (Wolfsburg/GER; 44/3), Mark McKenzie (Genk/BEL; 6/0), Tim Ream (Fulham/ENG; 46/1), Antonee Robinson (Fulham/ENG; 14/0), Miles Robinson (Atlanta United; 11/3), James Sands (New York City FC; 6/0), DeAndre Yedlin (Galatasaray/TUR; 66/0), Walker Zimmerman (Nashville SC; 17/2)

MIDFIELDERS (5): Kellyn Acosta (Colorado Rapids; 39/2), Tyler Adams (RB Leipzig/GER; 16/1), Sebastian Lletget (LA Galaxy; 31/7), Cristian Roldan (Seattle Sounders; 27/0), Jackson Yueill (San Jose Earthquakes; 15/0)

FORWARDS (6): Brenden Aaronson (RB Salzburg/AUT; 9/4), Konrad de la Fuente (Olympique Marseille/FRA; 3/0), Jordan Pefok (BSC Young Boys/SUI; 8/1), Ricardo Pepi (FC Dallas; 0/0), Christian Pulisic (Chelsea/ENG; 39/16), Josh Sargent (Norwich City/ENG; 18/5)

Honduras roster

GOALKEEPERS (3): Marlon Licona (Motagua; 0/0), Luis Lopez (Real España; 37/0), Edrick Menjivar (Olimpia; 3/0)

DEFENDERS (9): Danilo Acosta (LA Galaxy/USA; 1/0), Felix Crisanto (Olimpia; 25/0), Maynor Figueroa (Houston Dynamo/USA; 173/5), Jose Garcia (Olimpia; 2/0), Johnny Leveron (Olimpia; 42/4), Andy Najar (D.C. United/USA; 37/4), Marcelo Pereira (Motagua; 19/0), Diego Rodriguez (Motagua; 10/1), Allans Vargas (Real España; 7/0)

MIDFIELDERS (8): Kevin Arriaga (Marathon; 4/0), Bryan Acosta (FC Dallas/USA; 52/2), Deybi Flores (Panetolikos/GRE; 14/0), Boniek Garcia (Houston Dynamo/USA; 133/3), Alexander Lopez (Alajuelense/CRC; 42/6), Brayan Moya (Primeiro de Agosto/ANG; 9/2), Carlos Pineda (Olimpia; 9/0), Edwin Rodriguez (Olimpia; 9/1)

FORWARDS (6): Eddie Hernandez (Olimpia; 22/7), Anthony Lozano (Cadiz/ESP; 36/9), Romell Quioto (CF Montreal/CAN; 52/11), Rigoberto Rivas (Reggina/ITA; 12/0), Edwin Solano (Marathon; 6/1), Jonathan Toro (Academica/POR; 13/3)