CHICAGO – The U.S. men’s national team will face fifth-ranked Uruguay in St. Louis in the squad’s match before the start of the Concacaf Nations League Tuesday, Sept. 10.

That tournament will help determine qualifying for the 2022 FIFA World Cup. Kickoff is set for 8 p.m. ET and match will be broadcast live on FS1, Univision and TUDN.

The USMNT takes the field at Busch Stadium for only the second time, following the 6-1 win against St. Vincent & the Grenadines in a World Cup qualifier Nov. 13, 2015.

“We look forward to this challenge against an excellent Uruguayan team. They possess a mixture of top-level offensive difference makers and experienced defenders that have competed on the world stage for years,” USMNT head coach Gregg Berhalter said. “Part of the development of our team is being able to consistently compete against teams with the profile of Uruguay. In the National Team we also speak about the importance of tradition, and St. Louis has one of the great soccer legacies in the United States. We look forward to adding to that history in September.”

Since the start of the 2022 World Cup cycle, the USMNT has received contributions from two St. Louis natives. Fulham-based defender Tim Ream has represented the USA 35 times in international competition, including starts in five of six matches in the its run to the 2019 Concacaf Gold Cup final. Former St. Louis Scott Gallagher striker Josh Sargent won the Silver Ball as the second-leading scorer at the 2017 Under-20 World Cup and captained the U-17 World Cup team that same year. Now at Werder Bremen in the German Bundesliga, the 19-year-old has appeared eight times for the senior USMNT, scoring two goals.

Uruguay boasts an array of stars representing club champions from Spain, Italy and France. Its attack is led by Luis Suarez (FC Barcelona) and Edinson Cavani (Paris Saint-Germain), who have combined to score 106 goals for La Celeste. The Uruguayans reached the quarterfinals of the 2018 World Cup, falling to eventual champion France.

With the USA holding a 2-2-2 record against Uruguay, the match in St. Louis marks the seventh all-time meeting between the two nations and first in 17 years. An early powerhouse of international football, Uruguay already was four-time Copa America champions by the time of the first meeting with the USA at the 1924 Summer Olympics in Paris. Playing just its fourth-ever international match, the USMNT fell 3-0 that day to a Uruguay team that went onto win the inaugural 1930 FIFA World Cup and take its second title 20 years later in Brazil.

The teams last met in a tune-up for the 2002 World Cup, with the USA using goals from Tony Sanneh and DaMarcus Beasley to earn a 2-1 victory against La Celeste May 12, 2002 at RFK Stadium in Washington, D.C.